European Journal of Prosthodontics and Restorative Dentistry

Anti-Inflammatory and Regenerative Effects of Albanian Propolis in Experimental Vital Amputations


This study evaluated the effects of Albanian propolis on the inflamed pulpal tissue after pulpotomy in piglets. In five piglets, two teeth each were infected using special pathogenic microbial flora that was prepared in advance in order to cause inflammation of the pulp. Pulpotomy was performed in the maxillary and mandibular central and lateral incisors. Microbial flora pathogenesis prepared from the section of infected teeth, containing Staphylococcus aureus, Streptococcus viridans, Enterococcus faecalis, Staphylococcus albus and mixed flora were used to cause artificial pulpitis. The first group consisted of piglets with the teeth having pulpal inflammation and regeneration
without medication served as the control group. In the second group, the teeth were treated with pure propolis after vital amputation. In the 3rd, 4th and 5th groups, the teeth were treated after vital amputation with the compounds of ZnO+10%, ZnO+20% propolis in ethanol, and with the paste composed of Ca(OH)2+30% oily propolis, respectively. In half of the teeth, propolis based pastes were applied on the pulp and entries of the cavities were isolated with glass ionomer cement while the other half did not receive this treatment and acted as the control. The cavity entries were obturated with chemically polymerized resin composite. Inflammatory response, dominated by polymorphonuclear cells, was observed in the dental pulpal tissue of all the teeth that were not treated with propolis-based paste. Radiography and histopathology analyses were performed to survey the infected pulp tissue treated with propolis up to 3 months. Data were analysed using Mann-Whitney U test (α=0.05). After vital amputation of the pulp, application of Albanian propolis showed significantly higher anti-inflammatory and regenerative effect creating dentin barrier after 3 months of treatment compared to control group (p<0.05). These results were more expressed in the group containing 20% propolis in ethanol+ZnO.

Dentine bridge


Mutlu Özcan, Kastriot Shytaj, Bora Bimbari, Agron Meto, Aida Meto

Articles from this issue

Title / DOI Access Page Start Page End Purchase
‘Own-Label’ Versus Branded Commercial Dental Resin Composite Materials: Mechanical And Physical Property Comparisons
no access 122 129 £10.00
Marginal Adaptation, Gap Width, and Fracture Strength of Teeth Restored With Different All-Ceramic Vs Metal Ceramic Crown Systems: An in Vitro Study
no access 130 137 £10.00
Effects of Different Porcelains and Shades on Light Transmission and Resin Polymerization
no access 138 144 £10.00
Anti-Inflammatory and Regenerative Effects of Albanian Propolis in Experimental Vital Amputations
no access 145 151 £10.00
A Practice-Based Clinical Evaluation of a Bulk Fill Restorative Material
no access 152 157 £10.00
A Survey on Prevalence, Causes and Prevention of Postcementation Hypersensitivity
no access 158 163 £10.00
Fracture of Zirconia Abutment with Metallic Insertion on Anterior Single Titanium Implant with Internal Hexagon: Retrieval Analysis of a Failure
no access 164 168 £10.00
  • free access Free Access
  • no access No Access
  • full access Full Access