The Effect of Myo-Inositol on Sperm Parameters and Pregnancy Rate in Oligoasthenospermic Men Treated with IUI: A Randomized Clinical Trial
Myo-inositol, Infertility, Polycystic Ovary Syndrome (PCOS), Oligoasthenospermia, Reproductive health, Fertilization rates
AuthorsAbstractAim: This paper investigates the Myo-inositol supplementation in treating infertility related to oligoasthenospermia among men besides mentioning the increasing trend of infertility in the world. Methods: A randomized, double-blind, and placebo-controlled trial was done in Lady reading hospital, medical teaching institute, Peshawar, 60 men diagnosed with oligoasthenospermia were randomly allocated to receive 2 g of myo-inositol twice a day or a placebo after 3 months. The pre- and post-treatment semen analysis was conducted according to the WHO 2021 established standards. Supplanted couples received intrauterine insemination (IUI), in which ovulation was controlled and pregnancy was verified using serum 25 -hCG and ultrasound. Findings: Myo-inositol has demonstrated a possible beneficial outcome on sperms parameter, ovulation and fertilization rate in PCOS women. The ttest and Chi-square test were used in analyzing data at a significance level of p < 0.05. In men, it is associated with improvement of sperm maturation and motility among oligoasthenospermic individuals. Also, it can aid in the preservation of osmotic balance of seminal fluid, which is a positive factor in fertility. Summary: The results indicate the necessity to create awareness and interventions about infertility. Myo-inositol has a potential to be a useful solution to both genders in enhancing reproductive health. More studies are required to come up with holistic methods of treatment of infertility.
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