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European Journal of Prosthodontics and Restorative Dentistry  —  Vol. 34, Issue Special Issue 4 (July 2026) ← Back to issue
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Automated Oral Lesion Detection and Classification Using Computer Vision

DOI: 10.1922/ejprd.v34i4s.1475
Keywords

Oral lesion detection; YOLOv8; EfficientNet-B3; Grad-CAM; Oral cancer screening; Explainable AI; Tele-dentistry

Authors:

1

Dr. Anushree Raj
Mangalore Institute of Technology &
Engineering, Mangalore, Karnataka,
India, [email protected]

Dr. Shamna N V, P A College of
Engineering, Mangalore, Karnataka,
India, [email protected]
2

Venkatesh A, BMS Institute of
Technology
&
Management,
Bangalore,
Karnataka,
India,
[email protected]
3

Dr. Pallavi M O, Sapthagiri NPS
University,
Bangalore,
India,
[email protected]
4*

Dhananjaya B, Nitte (Deemed to be
University), NMAM Institute of
Technology, Nitte, Karkala, India,
[email protected]
5

Dr. Sandhya Madhuri G, Jain
University, Bangalore, Karnataka,
India,
[email protected]
6

Corresponding
[email protected]

Received-18-05-2026
Revised-22-06-2026
Accepted-25-06-2026

European Journal of Prosthodontics and Restorative Dentistry (2026) 34 (04s), 438–447

Automated Oral Lesion Detection and Classification Using Computer Vision

Abstract

Early diagnosis of oral lesions is a critical determinant of clinical outcomes in oral cancer management. Conventional screening relies on expert examination, which is prone to inter-observer variability and limited access in rural settings. This study proposes a hybrid deep learning framework integrating YOLOv8 for lesion localization with EfficientNet-B3 for multiclass classification. The pipeline automatically identifies suspicious intraoral lesions and categorizes them as Normal, Benign, Premalignant, or Malignant. Gradient-weighted Class Activation Mapping (Grad-CAM) provides discriminative heatmaps for clinical interpretability. Experiments on 5,200 annotated intraoral images yielded a detection mAP@50 of 96.8%, classification accuracy of 96.1%, and AUC-ROC of 98.2%, outperforming six state-of-the-art baselines. Ablation studies confirm the contribution of each component. The framework is suitable for tele-dentistry deployment with an inference time of 22 ms per image. ••••••••••••••••••••••••••••••• ejprd.org - Published by Riset Publication Services LLC

EJPRD

Copyright ©2026 by RisetPublicationServicesLLC

Article Information
Pages
438 – 447
Cover Date
July 2026
Volume
34
Issue
Special Issue 4
Print ISSN
0965-7452
Electronic ISSN
2396-8893