Clinical Effectiveness of Locally Delivered Camel Milk Whey Protein Gel as an Adjunct to Mechanical Plaque Debridement in Patients with Stage II Grade B Periodontitis: A Randomized Clinical Trial

Camel milk whey protein; periodontitis; professional mechanical plaque debridement; clinical attachment level; probing pocket depth; gingival index; local drug delivery; non-surgical periodontal therapy.

1Aya Ayman Ahmed Elnaggar,
Demonstrator of Oral Radiology, Faculty of Oral
and Dental Medicine, Kafr el-Sheikh University,
Kafrelsheikh, Egypt.
E-mail: [email protected]

2Nour Hatata,
Assistant Professor of Oral Radiology, Oral
Radiology Department, Faculty of Oral and
Dental Medicine, Kafr El-Sheikh University,
Kafrelsheikh, Egypt.
e-mail: [email protected]

3Nemany A. N. Hanafy,
Assistant Professor of Nanomedicine, Group of
Bionanotechnology and Molecular Cell Biology,
Nanomedicine Department, Institute of
Nanoscience and Nanotechnology, Kafrelsheikh
University, 33516 Kafrelsheikh, Egypt,
Koç University Research Center for Translational
Medicine (KUTTAM), 34450 Istanbul, Türkiye,
E-mail: [email protected]

4Hamada Deyab,
Lecturer of Orthodontics,
Department of Orthodontics, Dental Technology
Prosthodontics Program, Faculty of Applied
Health Sciences, Borg Al Arab Technological
University, Borg Al Arab, Alexandria, Egypt.
Ambassador of Royal College of Surgeons of Edinburgh
Examiner for the Royal College of Glasgow, England
E-mail: [email protected]

5Mohamed Yehia Abdelfattah,
Assistant Professor of Oral Biology,
Oral Biology Department, Faculty of Dentistry,
Beni- Suef University, Beni-Suef, Egypt.
Department of Basic Dental Sciences, Faculty of
Dentistry, Ibn Sina University for Medical
Sciences, Amman, Jordan.
E-mail: [email protected]

6Monica Magdi K.H. Bichay
General Dentist – Private Dental Clinic, Dubai,
UAE
E-mail: [email protected]

Address for correspondence: Walid Elamrousy,
Assistant Professor of periodontology,
Periodontology Department, Faculty of Oral and
Dental Medicine, Kafr el-Sheikh University,
Kafrelsheikh, Egypt.
E-mail: [email protected],
Orcid: https://orcid.org/0000-0002-8100-4411

Received: 21-06-2026
Revised: 27-07-2026
Accepted:03-08-2026

European Journal of Prosthodontics and Restorative Dentistry (2026) 34(7s), 1178–1187

Clinical Effectiveness of Locally Delivered Camel Milk Whey Protein Gel as an Adjunct to Mechanical Plaque Debridement in Patients with Stage II Grade B Periodontitis: A Randomized Clinical Trial

Objectives: The purpose of this study was to assess the clinical efficacy of locally administered CMWP gel as a supplement to PMPD in individuals with Stage II Grade B periodontitis. Methods: Thirty patients with Stage II Grade B periodontitis who were systemically healthy and between the ages of 18 and 40 were divided into two parallel groups at random (n = 15 each). Group II received PMPD followed by intra-pocket administration of CMWP gel, while Group I received PMPD followed by intra-pocket application of placebo gel. For four weeks in a row, the gel was applied once a week. Gingival index (GI), clinical attachment level (CAL), and probing pocket depth (PPD) were measured at baseline, three months, and six months. The main clinical comparisons were carried out across follow-up periods and between groups. Results: Over the course of the six months, both groups showed statistically significant improvements in every clinical measure that was assessed. Group I and Group II had similar baseline CAL (3.67 ± 0.36 mm vs. 3.60 ± 0.34 mm; p = 0.606). Group II's CAL was considerably lower than Group I's at three months (2.43 ± 0.37 mm vs. 2.87 ± 0.35 mm; p = 0.003), and this difference grew at six months (2.00 ± 0.33 mm vs. 2.63 ± 0.44 mm; p < 0.001). With CMWP, the overall CAL increase was substantially higher (1.60 ± 0.21 mm vs. 1.03 ± 0.44 mm; p < 0.001). Additionally, Group II's PPD reduction was significantly higher than Group I's, with a mean reduction of 1.43 ± 0.33 mm versus 0.94 ± 0.41 mm (p = 0.001). At six months, Group II's mean PPD (2.00 ± 0.28 mm) was considerably lower than Group I's (2.31 ± 0.34 mm; p = 0.011). In both groups, GI dramatically dropped. At three months, Group II's GI was considerably lower (0.60 ± 0.23 vs. 0.80 ± 0.25; p = 0.031), but at six months, the difference was not statistically significant (0.53 ± 0.27 vs. 0.62 ± 0.16; p = 0.306). Conclusion: Within the constraints of this trial, patients with Stage II Grade B periodontitis who received locally applied CMWP gel in addition to PMPD showed higher clinical attachment gain and a reduction in probing pocket depth than those who received PMPD alone. Additionally, CMWP seemed to hasten the initial decrease in gingival inflammation. According to these results, CMWP might be a useful supplementary local treatment for periodontal disease that doesn't require surgery. To verify its therapeutic effectiveness and elucidate its underlying mechanisms, larger clinical trials with longer follow-up and microbiological and biochemical evaluations are necessary.

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