Antimicrobial Activity in Chitosan-Treated Prosthetic Materials: A Systematic Review

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  • Isis de Araújo Ferreira Muniz
  • Débora e Silva Campos
  • Isabella Lima Arrais Ribeiro
  • Wellington Francisco Rodrigues
  • Sabrina Daniela da Silva
  • André Ulisses Dantas Batista
  • Paulo Rogério Ferreti Bonan


Objective: The antimicrobial effect of prosthetic materials treated with chitosan was systematically reviewed. Methods: The searches were carried out on PubMed/Medline, Scopus, ISI Web of Science, LILACS, Embase, and Open Grey with searches performed in March 2022. Selection of in vitro studies, data extraction and risk of bias analysis were performed following the PRISMA guidelines and registered at the Open Science Framework. The evaluated prosthetic materials corresponded to PMMA and tissue conditioner, treated with chitosan. Results: After evaluating the eligibility criteria, 11 articles were included for
the qualitative synthesis. The evaluated prosthetic materials corresponded to PMMA (n=8) and tissue conditioner (n=3). All studies performed the incorporation of chitosan in the tissue conditioner (n=3). Regarding PMMA, the use of chitosan as a denture cleanser was the most used (n=3), followed by incorporation (n=2), multilayers coating onto PMMA (n=2) and denture adhesive for PMMA (n=1). Chitosan has antimicrobial activity and is effective in the treatment of prosthetic materials in most studies, but it depends on some factors, such as the treatment method, the type and characteristics of the chitosan, the microorganism
evaluated, and its form of organization. Conclusion: Chitosan showed highly antimicrobial activity and was effective when used in prosthetic materials.

Anti-Infective Agents
Polymethyl Methacrylate
Denture Rebasing