Does the Incorporation of Graphene Oxide into PMMA Influence its Antimicrobial Activity?

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  • Izabela Ferreira
  • Beatriz D. Sahm
  • Oswaldo L. Alves
  • José A. M. Agnelli
  • Andrea C. dos Reis


Introduction: The increase in infectious diseases mediated by oral bacteria has been one of the most potent threats to human health, specifically to the elderly. Researchers seek to incorporate antimicrobial nanomaterials into PMMA to control the colonization of microorganisms and reduce deadly diseases. Objective: To conduct a systematic review to answer the question: “Does graphene oxide incorporated into polymethylmethacrylate influence its antimicrobial activity?” Methods: The electronic search was performed in PubMed, Embase, Web of Science, Scopus, and Google Scholar databases, and articles published until October 2021 were selected. The search terms were: (“acrylic resin” OR PMMA) AND (graphene OR “oxide graphene”) AND (antimicrobial OR antibacterial OR
“anti-infective agent”). The risk of bias analysis of the articles was performed using the quasi-experimental study assessment tool adapted from the JBI. Results: Two hundred and fifty-nine articles were found in the databases. After removing the duplicates, 245 were analyzed by title and abstract. Of these, 06 were selected for full reading, of which 03 met the eligibility criteria and were included in this systematic review. Conclusion: This systematic review’s findings can infer that the incorporation of graphene in the form of graphene-based coatings to PMMA showed antimicrobial effectiveness.

Graphene Oxide