European Journal of Prosthodontics and Restorative Dentistry

Effect of Nystatin with and without DMAHDM on Antifungal and Mechanical Properties of Acrylic Resins

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Cover Date

June 2023

Print ISSN

0965-7452

Electronic ISSN

2396-8893

Vol

31

Issue

2

Abstract

Purpose: To investigate antifungal and mechanical properties after the impregnation of
Dimethyl Amino-ethyl Hexa-decyl Di-methacrylate (DMAHDM) alone or in combination
with Nystatin in polymethylmethacrylate. Methodology: The control group was
fabricated by mixing powder and liquid of PMMA at the ratio of 2.5:1 g/mL. The DMAHDM
was added to PMMA liquid and were mixed with PMMA powder. The Nystatin (500,000
International Units (IU)) was mixed with PMMA powder, whereby the composite powder
was mixed with the DMAHDM-based liquid. The prepared specimens were tested for
fungal adhesion testing (at days 1 and 30), impact strength and flexural strength.
Oneway ANOVA post-hoc Tukey’s test were used for statistical analysis. Results:
Statistical analysis for the adhesion assay revealed that the antifungal activities of
unaged and aged specimens in experimental groups were statistically significant as
compared to control group A. The groups containing DMAHDM with Nystatin have shown
statistically reduced flexural strength. The impact strength test revealed that groups
containing 20% DMAHDM alone and DMAHDM with Nystatin showed statistically
reduced impact strength compared to the control group. Conclusion: Antifungal
activities of experimental PMMA resin was increased. The addition of DMAHDM alone
in PMMA resin has no deleterious effects on impact and flexural strength, however, at
higher concentration values were reduced.

Keywords
Poly (methyl methacrylate)
Mechanical Properties
Antifungal
Nystatin
DMAHDM
Dental Polymer